ACACA

乙酰辅酶a羧化酶(acc)是一个复杂的多功能酶系统。acc是一种生物素酶,催化乙酰辅酶a羧化为丙二酰辅酶a,这是脂肪酸合成的限速步骤。ACC有两种形式,α和β,由两种不同的基因编码ACCα在成脂组织中高度富集该酶在转录和翻译水平上处于长期控制之下,通过靶向丝氨酸残基的磷酸化/去磷酸化和柠檬酸盐或棕榈酰辅酶a的变构转化处于短期调节之下在5'序列中有多个不同的选择性剪接转录变异体,并且编码不同的亚型[由RefSeq提供,2008年7月]
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

别名

ACC,ACAC,ACC1,ACCA,ACACAD

基因id

Chromosome:17 Start: 35441927 End: 35766902 Strand: 

药物

突变与药物

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相关基因检测

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