BCL2 IGH-BCL2

典型的T(14;18)(q32;q21)易位涉及14号染色体上免疫球蛋白重链位点与18号染色体上bcl2的3’utr之间的重排,导致bcl2的过度表达。滤泡性淋巴瘤患者中有80%的患者出现这种后延。
The typically reciprocal t(14;18)(q32;q21) translocation involves rearrangement between the immunoglobulin heavy chain locus on chromosome 14 and the 3' UTR of BCL2 on chromosome 18, leading to the overexpression of BCL2. This rearrangment is observed in \u003e80% of patients with follicular lymphoma.

别名

RECIPROCAL T(14;18)(Q32;Q21)
Allele Registry ID:
ClinVar ID:

突变位点

Ref. Build: GRCh37   Ensembl Version: 75
Chr.StartStopRef. sVar. Bases
14106032614107288051
Transcript
COORDINATE 2
Chr.StartStopTranscript
186079426860987019ENST00000333681.4

基因序列