BRAF K483M

K483M变异体是BRAF催化位点的一种激酶功能缺失变异体。在评估其他BRAF变体时，这种工程化变体通常用作控制。
The K483M variant is a kinase dead loss-of-function variant in the catalytic site of BRAF. This engineered variant is often used as a control when evaluating other BRAF variants.