DNMT3A

CpG甲基化是一种表观遗传修饰,对胚胎发育、印记和X染色体失活具有重要意义。对小鼠的研究表明,DNA甲基化是哺乳动物发育所必需的。这个基因编码一种DNA甲基转移酶,被认为在从头甲基化中起作用,而不是维持甲基化。该蛋白定位于细胞质和细胞核,其表达受发育调节。
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated.

别名

DNMT3A2,M.HsaIIIA,TBRS

基因id

Chromosome:2 Start: 25455845 End: 25565459 Strand: -1

突变与药物

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