EZH2 Y646

Y646突变与生发中心B型DLBCL和滤泡性非霍奇金淋巴瘤的诊断有关。体外实验结果表明，这可能是因为EZH2对蛋白质H3K27的甲基转移酶活性降低（Morin等人，2010年）。
Mutations of Y646 are associated with a diagnosis of Germinal Center B type DLBCL and Follicular non-Hodgkin Lymphoma. In vitro experimental findings suggest that this may be due to reduced methyltransferase activity of EZH2 on protein H3K27 (Morin et al., 2010).