FAT2

该基因是果蝇脂肪基因的第二个人类同源基因,它编码一种在果蝇发育过程中控制细胞增殖所必需的肿瘤抑制因子。该基因产物是钙粘蛋白超家族的一员,是一组完整的膜蛋白,具有钙粘蛋白型重复序列。该基因产物除含有34个钙黏蛋白串联重复序列外,还含有两个表皮生长因子(EGF)样重复序列和一个层粘连蛋白G结构域这种蛋白很可能是一种细胞粘附分子,控制细胞增殖,在小脑发育中起重要作用[由RefSeq提供,2008年7月]
This gene is the second identified human homolog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has two epidermal growth factor (EGF)-like repeats and one laminin G domain. This protein most likely functions as a cell adhesion molecule, controlling cell proliferation and playing an important role in cerebellum development. [provided by RefSeq, Jul 2008]

别名

CDHF8,CDHR9,HFAT2,MEGF1,SCA45

基因id

Chromosome:5 Start: 150883653 End: 150948505 Strand: 

药物

突变与药物

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