GALNT12

该基因编码udp-galnac家族的一个成员:多肽n-乙酰半乳糖胺基转移酶,在o-连接蛋白糖基化的初始步骤中催化n-乙酰半乳糖胺(galnac)从udp-galnac转移到多肽受体上的丝氨酸或苏氨酸残基。这个基因的突变与结直肠癌易感性的增加有关。
This gene encodes a member of a family of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases, which catalyze the transfer of N-acetylgalactosamine (GalNAc) from UDP-GalNAc to a serine or threonine residue on a polypeptide acceptor in the initial step of O-linked protein glycosylation. Mutations in this gene are associated with an increased susceptibility to colorectal cancer.[provided by RefSeq, Mar 2011]

别名

CRCS1,GalNAc-T12

基因id

Chromosome:9 Start: 101569981 End: 101612363 Strand: 

药物

突变与药物

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相关基因检测

genes