HDAC6

组蛋白在转录调控、细胞周期进展和发育事件中起着关键作用。组蛋白乙酰化/去乙酰化改变染色体结构并影响转录因子对dna的获取。该基因编码的蛋白属于组蛋白去乙酰化酶/acuc/apha家族的Ⅱ类。它包含两个催化结构域的内部复制,这两个催化结构域看起来相互独立。该蛋白具有组蛋白脱乙酰酶活性并抑制转录。[由RefSeq提供,2008年7月]
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq, Jul 2008]

别名

HD6,JM21,CPBHM,PPP1R90

基因id

Chromosome:X Start: 48660086 End: 48683408 Strand: 

药物

突变与药物

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相关基因检测

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