KRAS G12V

Kras突变是胰腺癌中最常见的突变，在90%的病例中发生。其中，G12d激活突变最为普遍，导致GTPase活性丧失，进而导致Kras的组成性活性形式。这足以引起癌前胰腺上皮内病变。
KRAS mutations are the most common mutations in pancreatic cancer occurring in \u003e 90% of cases. Of these the G12D activating mutation is the most prevalent and results in a loss of GTPase activity which in turn leads to a constitutively active form of KRAS. This is enough to cause pre-cancerous pancreatic intraepithelial lesions