MAP2K1 P124S

MAP2K1 p124S是黑色素瘤的一种复发性突变，在膀胱癌和结肠癌中的发病率较低。p124s突变被证明对黑色素瘤细胞株中的azd6244抵抗有贡献，但比其q56p对应物小得多。
MAP2K1 P124S is a recurrent mutation in melanoma, and is seen in bladder and colon cancer to a lesser degree. The P124S mutation has been shown to contribute to AZD6244 resistance in melanoma cell lines, but considerably less so than its Q56P counterpart.