PML PML-RARA

PML-RARA融合被认为是急性早幼粒细胞白血病（APL）的诊断事件。体外和体内研究均表明，携带PML-RARA融合的APL患者对ATRA的敏感性。最近人们对ATRA和三氧化二砷联合治疗这些患者的研究显示出了兴趣，早期的结果似乎是有希望的。
The PML-RARA fusion is seen as a diagnostic event in acute promyelocytic leukemia (APL). Both in vitro and in vivo studies have shown sensitivity to ATRA in APL patients harboring the PML-RARa fusion. Recent interest has been shown in combining ATRA and arsenic trioxide for treating these patients, and early results seem promising.