PPARG

该基因编码核受体过氧化物酶体增殖激活受体(ppar)亚家族的一个成员。ppar与维甲酸x受体(rxrs)形成异二聚体,这些异二聚体调节各种基因的转录。已知三种ppar亚型:pparα、pparδ和pparγ。该基因编码的蛋白是pparγ,是脂肪细胞分化的调节因子。此外,pparγ还与许多疾病的病理学有关,包括肥胖、糖尿病、动脉粥样硬化和癌症。另外,还描述了编码不同亚型的剪接转录变体。[由RefSeq提供,2008年7月]
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]

别名

GLM1,CIMT1,NR1C3,PPARG1,PPARG2,PPARgamma

基因id

Chromosome:3 Start: 12329349 End: 12475855 Strand: 

药物

突变与药物

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