SH2D1A

这个基因编码一种蛋白质,在双向刺激T和B细胞中起主要作用。这种蛋白质含有SH2结构域和短尾。它与信号淋巴细胞活化分子相结合,从而通过阻止含有shp-2信号转导分子的sh2结构域进入其对接位点而起到抑制这种跨膜蛋白的作用。这种蛋白质还可以与活化的t、b和nk细胞上表达的其他相关表面分子结合,从而改变这些细胞的信号转导途径。该基因突变导致淋巴增生综合征x连锁1型或duncan病,一种罕见的免疫缺陷,其特征是极易感染eb病毒,症状包括严重的单核细胞增多症和恶性淋巴瘤。已发现该基因编码不同亚型的多个转录变体。[由RefSeq提供,2008年7月]
This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

别名

LYP,SAP,XLP,DSHP,EBVS,IMD5,XLPD,MTCP1,XLPD1,SAP/SH2D1A

基因id

Chromosome:X Start: 123480132 End: 123507010 Strand: 

药物

突变与药物

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