TCL1A

TCL1基因在人类中的过度表达与成熟T细胞白血病的发生有关,其中染色体重排使TCL1基因接近T细胞抗原受体(TCR)-α(MIM 186880)或TCRβ(MIM 186930)调节元件(由VygILIO等,1998 [PubMed 9520462 ]概括)。在正常T细胞中,TCL1在CD4-/CD8-细胞中表达,但在分化后期细胞中不表达TCL1作为细胞存活激酶AKT(MIM 164730)的辅活化子(Laine等人,2000年[出版编号10983986])。[由OMIM提供,2010年7月]
Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010]

别名

TCL1

基因id

Chromosome:14 Start: 96176304 End: 96180533 Strand: 

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突变与药物

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