TP53 P72R

这种多态性在不同癌症类型中被广泛研究,但迄今为止,在乳腺癌、肺癌和宫颈癌队列中的荟萃分析尚未确定患者基因型在该位点的重要性,因为它与癌症易感性和预后有关。
This polymorphism is relatively widely studied across cancer types, but meta-analyses in breast, lung and cervical cancer cohorts have so far been inconclusive as to the significance of a patient's genotype at this locus as it relates to cancer susceptibility and prognosis.

别名

PRO72ARG,P33R,RS1042522
Allele Registry ID:CA000072
ClinVar ID:12351

突变位点

Ref. Build: GRCh37   Ensembl Version: 75
Chr.StartStopRef. sVar. Bases
1775794727579472GC
Transcript
ENST00000269305.4

基因序列

NM_000546.5:c.215C>003eG
NP_000537.3:p.Pro72Arg
NC_000017.10:g.7579472G>003eC
ENST00000269305.4:c.215C>003eG