TRAF5

该基因编码的支架蛋白是肿瘤坏死因子受体相关因子(traf)蛋白家族的成员,包含meprin和traf同源性(math)结构域、一个环状锌指和两个traf型锌指。traf蛋白与肿瘤坏死因子受体超家族成员相关,并介导其信号转导。该蛋白是与肿瘤坏死因子(TNF)受体胞质结构域结合并介导TNF诱导活化的多蛋白复合物的组成部分之一。已发现该基因编码不同亚型的多个转录变体。[由RefSeq提供,2016年1月]
The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor (TRAF) protein family and contains a meprin and TRAF homology (MATH) domain, a RING-type zinc finger, and two TRAF-type zinc fingers. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein is one of the components of a multiple protein complex which binds to tumor necrosis factor (TNF) receptor cytoplasmic domains and mediates TNF-induced activation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

别名

RNF84,MGC:39780

基因id

Chromosome:1 Start: 211499849 End: 211548403 Strand: 

药物

突变与药物

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