WT1 EXON 9 MUTATION

WT1外显子9突变在急性髓性白血病中被证明是复发性的，尽管其发生率低于其外显子7突变。许多来源已经研究了这些基因的预后影响，一致认为突变外显子9队列与更差的总生存率和一些不良预后相关。这可能是由于wt1突变肿瘤对化疗反应不佳所致。
WT1 exon 9 mutations have been shown to be recurrent in acute myeloid leukemia, although at a less frequent rate than their exon 7 counterparts. Many sources have examined the prognostic impact of these, agreeing that the mutant exon 9 cohort is correlated with worse overall survival and a number of poor prognistic outcomes. This may be the result of an overall poor response to chemotherapy from WT1 mutant tumors.