ACSL3

该基因编码的蛋白质是长链脂肪酸辅酶a连接酶家族的同工酶。尽管在底物特异性、亚细胞定位和组织分布上存在差异，但该家族的所有同工酶都能将游离的长链脂肪酸转化为脂肪酰辅酶a酯，从而在脂肪生物合成和脂肪酸降解中发挥关键作用。这种同工酶在大脑中高度表达，并优先利用肉豆蔻酸盐、花生四烯酸盐和二十碳五烯酸盐作为底物该同工酶的氨基酸序列与大鼠同系物的氨基酸序列一致性达92%。在这个基因中发现了两个编码相同蛋白质的转录变体。[由RefSeq提供，2008年7月]
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]