ASXL1 MUTATION

急性髓系白血病（AML）患者中最常见的ASXL1突变是在没有FLT3-ITD和NPM1突变的情况下观察到的，并且似乎在老年患者中更为丰富（\u003E60岁）。这些突变与生存率和竞争缓解率预后不良相关。
ASXL1 mutations are most frequently observed in the absence of FLT3-ITD and NPM1 mutations in acute myeloid leukemia (AML) patients and seem to be enriched in older patients (\u003e60 years). These mutations are associated with poor prognosis with respect to both survival and compete remission rates.