BCL11B

该基因编码C2H2型锌指蛋白，与BCL11A基因密切相关，BCL11A基因的易位可能与B细胞恶性肿瘤有关尽管该基因的特异功能尚未确定，但编码的蛋白已知是一种转录抑制因子，由NURD核小体重塑和组蛋白脱乙酰酶复合物调节已经发现四个选择性剪接的转录变体编码不同的亚型[由RefSeq提供，2013年8月]
This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. Although the specific function of this gene has not been determined, the encoded protein is known to be a transcriptional repressor, and is regulated by the NURD nucleosome remodeling and histone deacetylase complex. Four alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Aug 2013]