BUB1B

这个基因编码一个参与纺锤体检查点功能的激酶。该蛋白已定位于动粒,并在抑制后期促进复合物/环小体(apc/c)中发挥作用,延缓后期的发生,确保染色体的正确分离。纺锤体检查点功能受损已在多种癌症中发现。[由RefSeq提供,2008年7月]
This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. [provided by RefSeq, Jul 2008]

别名

MVA1,SSK1,BUBR1,Bub1A,MAD3L,hBUBR1,BUB1beta

基因id

Chromosome:15 Start: 40453210 End: 40513337 Strand: 

药物

突变与药物

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