CDKN2A p16 EXPRESSION

CDKN2A（p16）的表达是口咽鳞癌中hpv感染的替代标志物。CDKN2A和P53通过hpv蛋白E6和E7失活，因此在hpv相关癌中表达水平没有改变。然而，p16表达和hpv状态之间没有完全重叠，大约10-12.5%的hpv阴性肿瘤表达p16。（Seiwert，T JCO，2014年）。p16在原发性头颈部鳞状细胞癌中是一个公认的阳性预后因子，正如越来越多的证据所表明的，复发/转移性疾病环境。到目前为止，还没有确定来自hpv状态的预测信息。一些研究表明，EGFR抑制剂缺乏益处。其他的研究无法重现这一发现。
CDKN2A (p16) expression is a surrogate marker of HPV infection in oropharyngeal squamous cell carcinoma. CDKN2A and p53 are inactivated through HPV proteins E6 and E7 and therefore not altered in expression level in HPV-associated carcinomas. However, there is no perfect overlap between p16 expression and HPV status with some 10-12.5% of HPV-negative tumors expressing p16. (Seiwert, T JCO, 2014). p16 positivity is a well-established positive prognostic factor in squamous cell cancer of the head and neck in the primary and, as increasing evidence suggests, recurrent/metastatic disease settings. Predictive information from HPV status have not been established to date. A lack of benefit from EGFR-inhibitors has been proposed by some studies. Other studies were not able to reproduce this finding.