EGFR VIII

egfrviii变异体是一种致癌突变，已在包括多形性胶质母细胞瘤、乳腺癌、肺癌、头颈癌、卵巢癌和前列腺癌在内的多种癌症中报道。在高级别胶质瘤中，约30%的EGFR扩增病例报告了EGFRVIII。egfrviii突变导致受体外域外显子2-7缺失。这种变异的存在与临床对eGFR-tki的反应有关。（Arteaga和Engelmann，2014年）
The EGFRvIII variant is an oncogenic mutation that has been reported in several cancers including glioblastoma multiforme, breast, lung, head and neck, ovarian and prostate. In high-grade gliomas, EGFRvIII has been reported in about 30% of cases with EGFR amplification. The EGFRvIII mutation leads to deletion of the receptor ectodomain exons 2-7. The presence of this variant has been linked with clinical response to EGFR TKI. (Arteaga and Engelmann, 2014)