EIF4G3

该基因编码的蛋白被认为是eif4f蛋白复合物的一部分，参与mrna帽识别和mrnas向核糖体的转运。有趣的是，一种microRNA（miR-520c-3p）被发现对编码蛋白的合成具有负性调节作用，这导致了蛋白质翻译和细胞增殖的全面减少因此，该蛋白是mir-520c-3p抗肿瘤活性的关键组成部分。[由refseq提供，2016年5月]
The protein encoded by this gene is thought to be part of the eIF4F protein complex, which is involved in mRNA cap recognition and transport of mRNAs to the ribosome. Interestingly, a microRNA (miR-520c-3p) has been found that negatively regulates synthesis of the encoded protein, and this leads to a global decrease in protein translation and cell proliferation. Therefore, this protein is a key component of the anti-tumor activity of miR-520c-3p. [provided by RefSeq, May 2016]