F3

该基因编码凝血因子iii，它是一种细胞表面糖蛋白。该因子使细胞启动凝血级联反应，并作为凝血因子VII的高亲和力受体发挥作用由此产生的复合物提供了一种催化事件，该催化事件负责通过特定的限制性蛋白水解引发凝血蛋白酶级联。与这些蛋白酶级联的其他辅因子不同，这些辅因子作为非功能性前体循环，当在细胞表面表达时，这个因子是一个有效的引发剂，具有完全的功能。该因子有3个不同的结构域：细胞外、跨膜和细胞质。这种蛋白质是凝血途径中唯一一种尚未被描述为先天性缺陷的蛋白质交替剪接导致多个转录变体。[由RefSeq提供，2010年5月]
This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]