FKBP5

该基因编码的蛋白质是免疫亲和蛋白家族的一员，在蛋白质折叠和转运的免疫调节和基本细胞过程中发挥作用。该编码蛋白是一种顺反-脯氨酸异构酶，与免疫抑制剂FK506和雷帕霉素结合。它被认为是介导钙调磷酸酶抑制。它还与成熟的异寡聚孕酮受体复合物以及90kDa热休克蛋白和P23蛋白在功能上相互作用这个基因被发现有多个聚腺苷酸化位点选择性剪接导致多个转录变体。[由RefSeq提供，2009年3月]
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]