FLT3 T227M

根据外显子聚集联合会（Exac）的数据，flt3t27m（rs1933437）是一种常见的多态性，其GMaf约为.60。它在癌症倾向中的作用尚不清楚，但它可能与舒尼替尼治疗患者白细胞减少症的发展有关。
FLT3 T227M (rs1933437) is a common polymorphism with a GMAF around .60 based on the Exome Aggregation Consortium (ExAC) data. Its role in cancer predisposition is still unknown, however it may be associated with the development of leukopenia in patients treated with sunitinib.

别名

RS1933437,THR227MET
Allele Registry ID：CA159846
ClinVar ID：134447

突变位点

Ref. Build: GRCh37 Ensembl Version: 75

Chr.	Start	Stop	Ref. s	Var. Bases
13	28624294	28624294	G	A
Transcript
ENST00000241453.7

基因序列

NM_004119.2:c.680C>003eT
NP_004110.2:p.Thr227Met
NC_000013.10:g.28624294G>003eA