FLT3 TKD MUTATION

与flt3-itd（内部串联重复）突变相比，flt3酪氨酸激酶域突变（flt3-tkd）的发生率要低得多，可能不会产生相同的预后影响。虽然大多数突变是影响D835的点突变（最常见的是D835Y），但有一小部分涉及I836的帧内缺失。这些突变位于FLT3的第二个酪氨酸激酶域的激活环内，并被认为导致受体的组成性激活。
FLT3 tyrosine kinase domain mutations (FLT3-TKD) are much less common than FLT3-ITD (internal tandem duplication) mutations and may not confer the same prognostic impact. Although the majority of mutations are point mutations effecting D835 (most frequently D835Y), a small proportion involve an in-frame deletion of I836. These mutations are within the activation loop of the second tyrosine kinase domain of FLT3 and thought to result in constitutive activation of the receptor.