FN1

该基因编码纤维连接蛋白，一种在血浆中以可溶性二聚体形式存在的糖蛋白，在细胞表面和细胞外基质中以二聚体或多聚体形式存在。编码的前蛋白经蛋白质水解处理生成成熟蛋白。纤维连接蛋白参与细胞粘附和迁移过程，包括胚胎发生、伤口愈合、凝血、宿主防御和转移。该基因有三个可供选择剪接的区域，有可能产生20种不同的转录变体，其中至少一种编码经过蛋白水解处理的亚型。一些变体的全长性质尚未确定。[由RefSeq提供，2016年1月]
This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. The full-length nature of some variants has not been determined. [provided by RefSeq, Jan 2016]