GATA2 EXPRESSION

GATA2在一些血液学恶性肿瘤以及非小细胞肺癌中被观察到失调。用蛋白酶体抑制剂bortezomib治疗过度活跃的GATA2途径在肺癌中显示出显著的肿瘤消退。
GATA2 misregulation has been observed in a number of hematologic malignancies, as well as non-small cell lung cancer. Treatment of over-active GATA2 pathways using the proteasome inhibitor bortezomib has shown dramatic tumor regression in lung cancer.