IDH2 R172K

在一些血液学恶性肿瘤中观察到IDH2突变。在急性髓系白血病中，与IDH2野生型患者相比，R172K突变与较差的预后和较差的总生存率有关。然而，在骨髓置换综合征中，研究没有发现这种变异与患者结局之间的预后关联。
IDH2 mutations have been observed in a number of hematologic malignancies. In acute myeloid leukemia, the R172K mutation has been linked with poorer prognosis and worse overall survival than IDH2 wild-type patients. However, in myelodisplastic syndromes, studies did not find a prognostic association between this variant and patient outcomes.