LATS1

该基因编码的蛋白是一种推测的丝氨酸/苏氨酸激酶，在有丝分裂早期定位于有丝分裂器并与细胞周期调控因子cdc2激酶复合。蛋白质以细胞周期依赖的方式磷酸化，晚期前期磷酸化通过中期保持。蛋白的n-末端区域与cdc2结合形成复合物，显示h1组蛋白激酶活性降低，表明cdc2/cyclin a的负调节作用。此外，c-末端激酶区域与自身的n-末端区域结合，通过分子内结合干扰复合物的形成，提示潜在的负调节作用。生化和遗传数据表明，它是一种肿瘤抑制因子。这一点得到了基因敲除小鼠研究的支持，研究表明，小鼠体内存在软组织肉瘤、卵巢基质细胞瘤以及对致癌治疗的高度敏感性。[由RefSeq提供，2017年4月]
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. [provided by RefSeq, Apr 2017]