MKNK2

该基因编码钙/钙调素依赖性蛋白激酶（camk）ser/thr蛋白激酶家族的一个成员，属于蛋白激酶超家族。该蛋白含有保守的dlg（asp-leu-gly）和enil（glu-asn-ile-leu）基序，以及一个结合导入蛋白a和翻译因子支架蛋白真核起始因子4g（eif4g）的n末端多元酸区。该蛋白是丝裂原活化蛋白（MAP）激酶激活的下游激酶之一。它使真核细胞起始因子4e（eif4e）磷酸化，从而在mrna翻译、癌基因转化和恶性细胞增殖中发挥重要作用。除eif4e外，该蛋白还与von hippel-lindau肿瘤抑制因子（vhl）、环盒1（rbx1）和culli2（cul2）相互作用，这些都是cbc（vhl）泛素连接酶e3复合物的组成部分。已发现多个选择性剪接的转录变体，但仅确定两个变体的全长性质和生物活性。这两个变种编码不同的亚型，它们在活性和调节以及亚细胞定位上不同。[由RefSeq提供，2011年8月]
This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex. Multiple alternatively spliced transcript variants have been found, but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation, and in subcellular localization. [provided by RefSeq, Aug 2011]