NAB2

该基因编码ngfi-a结合（nab）蛋白家族的一个成员，其在细胞核中的功能是抑制由egr（早期生长反应）反式激活因子家族的一些成员诱导的转录。nab蛋白可以通过一个保守的n端结构域与其他egr或nab蛋白同源或异源多聚，并通过两个部分冗余的c端结构域抑制转录。编码蛋白的转录抑制部分是通过与核小体重塑和脱ctylase（nurd）复合物的相互作用介导的。已经描述了选择性剪接的转录变体，但其生物学有效性尚未确定。[由RefSeq提供，2008年7月]
This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]