NFKB1

该基因编码一个105kd蛋白，该蛋白可以通过26s蛋白酶体进行共翻译处理，产生一个50kd蛋白。105kd蛋白是Rel蛋白特异性转录抑制剂，50kd蛋白是NF-kappa-B（NFKB）蛋白复合物的DNA结合亚基NFKB是一种转录调节因子，通过细胞内、细胞外的刺激，如细胞因子、氧化自由基、紫外线照射和细菌或病毒产物激活。激活的nfkb转运到细胞核中，刺激参与多种生物学功能的基因表达。nfkb的不适当激活与许多炎症性疾病有关，而nfkb的持续抑制导致免疫细胞发育不适当或细胞生长延迟。选择性剪接导致编码不同亚型的多个转录变体，其中至少一个是经过蛋白质水解处理的[由RefSeq提供，2016年2月]
This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed. [provided by RefSeq, Feb 2016]