NOTCH1 P2514FS

这种突变破坏了正常条件下促进降解的C末端害虫结构域，导致活性Notch1亚型的积累，从而维持解除管制的信号传导。
This mutation disrupts the C-terminal PEST domain that in normal conditions promotes degradation, resulting in accumulation of an active NOTCH1 isoform sustaining deregulated signaling.