PIK3CA H1047R

PIK3CA H1047R是癌症特别是乳腺癌中最常见的单核苷酸变异之一。在PIK3CA突变型乳腺癌中，有一半以上含有这种突变。荟萃分析表明，携带这种突变的患者总体生存率可能更差，但从预后的角度来看，其他研究显示H1047R和其他PIK3CA突变体没有差异。尽管非常普遍，但针对这种特殊突变的靶向治疗仍处于早期临床试验阶段。
PIK3CA H1047R is one of the most recurrent single nucleotide variants in cancer, especially breast cancer. Of PIK3CA-mutant breast cancers, over half harbor this mutation. Meta-analyses have shown that patients harboring this mutation may have worse overall survival, but other studies have shown no difference between H1047R and other PIK3CA mutants from a prognostic standpoint. While very prevalent, targeted therapies for this particular mutation are still in early clinical trial phases.