PTEN R233*

PTEN R233*已被证明是一种功能缺失突变，PTEN缺失已成为乳腺癌大量研究的主题。PTEN缺失可能使细胞对PI3K mTOR抑制敏感。尽管仍有争议，但有数据支持PTEN丢失与预后不良相关，且预后无变化。
PTEN R233* has been shown to be a loss of function mutation, and PTEN loss has been the subject of considerable research in breast cancer. PTEN loss may sensitize cells to PI3K-mTOR inhibition. While still being debated, there is data to support that PTEN loss is both associated with poorer prognosis, and no change in prognosis.