PTK2

该基因编码一种细胞质蛋白酪氨酸激酶，该蛋白酪氨酸激酶集中于在细胞外基质成分存在下生长的细胞间形成的局部粘连中。该编码蛋白是蛋白酪氨酸激酶fak亚家族的一员，但与其它亚家族的激酶缺乏明显的序列相似性。该基因的激活可能是细胞生长和细胞内信号转导途径中的一个重要的早期步骤，它是对某些神经肽或细胞与细胞外基质相互作用的反应。已经发现了一些编码不同亚型的转录变体。[由RefSeq提供，2017年6月]
This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017]