TCF7L2

该基因编码一个高迁移率族（hmg）盒，包含在wnt信号通路中起关键作用的转录因子。这种蛋白质与血糖稳态有关。这种基因的遗传变异与2型糖尿病风险增加有关。已经发现了该基因编码多种不同亚型的转录变体。[由RefSeq提供，2010年10月]
This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]