TGFBR3

该位点编码转化生长因子（TGF）-β-III型受体。编码受体是一种膜蛋白多糖，通常与其他TGFβ受体超家族成员作为共受体发挥作用。胞外域脱落产生可溶性TGFBR3，可能抑制TGFB信号传导。在各种癌症中观察到这种受体的表达降低。另外，编码不同亚型的剪接转录变体已被鉴定为该基因。
This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.