TRAF2

该基因编码的蛋白是肿瘤坏死因子受体相关因子（traf）蛋白家族的一员。traf蛋白与肿瘤坏死因子受体超家族成员相关并介导其信号转导。这种蛋白质直接与TNF受体相互作用，并与TRAF1形成异二聚体复合物。这种蛋白是肿瘤坏死因子α介导的mapk8/jnk和nf-kappab活化所必需的。由该蛋白和traf1形成的蛋白复合物与凋亡抑制蛋白（iaps）相互作用，并充当来自肿瘤坏死因子受体的抗凋亡信号的介质。该蛋白与肿瘤坏死因子受体相关的凋亡信号转导子tradd的相互作用确保了iaps的募集，从而直接抑制caspase的激活。birc2/c-iap1是一种具有泛素连接酶活性的细胞凋亡抑制剂，能使该蛋白脱水解酶并诱导其降解，从而增强肿瘤坏死因子诱导的细胞凋亡。已发现该基因的多个选择性剪接转录变体，但仅确定了一个转录的生物学有效性。[由RefSeq提供，2008年7月]
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined. [provided by RefSeq, Jul 2008]