TSC2

这个基因的突变导致结节性硬化症。其基因产物被认为是一种肿瘤抑制因子,能够刺激特定的GTP酶。这种蛋白在细胞溶质复合体中与哈马汀结合,可能作为哈马汀的伴侣。选择性剪接导致编码不同亚型的多个转录变体。
Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms.

别名

LAM,PPP1R160,TSC4

基因id

Chromosome:16 Start: 2097466 End: 2138716 Strand: 1

药物

突变与药物

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相关基因检测

genes