U2AF1 S34Y/F

u2af1 s34y/f是急性髓性白血病（AML）、骨髓增生异常综合征（MDS）和肺腺癌的复发性突变。这种突变是MDS中最常见的变异，发生在u2af1的第一个锌指区域，并已被证实改变了剪接。u2af1突变对MDS总生存率的影响一直存在争议，然而，u2af1突变的患者被证明具有向继发性AML转化的风险增加。与u2af1野生型患者相比，这种突变的存在与AML的特定预后无关。
U2AF1 S34Y/F has been shown to be a recurrent mutation in acute myeloid leukemia (AML), myelodysplastic syndromes (MDS) and lung adenocarcinomas. This mutation is the most commonly identified variant in MDS, occurs in the first zinc finger domain of U2AF1 and has been demonstrated to alter splicing. The impact of U2AF1 mutations on overall survival in MDS has been debated, however, patients with U2AF1 mutations were shown to be at an increased risk of transformation to secondary AML. The presence of this mutation was not associated with a specific prognostic outcome in AML when compared to U2AF1 wildtype patients.