Phosphatase And Tensin Homolog
全名
别名
BZS,DEC,CWS1,GLM2,MHAM,TEP1,MMAC1,PTEN1,10q23del,PTENbeta
基因id
HGNC: 9588; Entrez Gene: 5728; Ensembl: ENSG00000171862; OMIM: 601728; UniProtKB: P60484
序列
基因组
靶向药
参考文献
1. Sos ML. et al. PTEN loss contributes to erlotinib resistance in EGFR-mutant lung cancer by activation of Akt and EGFR. Cancer Res. 2009
2. Courtney KD. et al. The PI3K pathway as drug target in human cancer. J Clin Oncol. 2010
3. Neshat MS. et al. Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR. Proc Natl Acad Sci U S A. 2001