职称：教授　主任医师

现就职医院：第四军医大学西京医院

擅长：结直肠癌

吴开春，男，主任医师，教授，博士生导师。现就职于第四军医大学西京医院，任第四军医大学西京消化病医院副院长，教育部“长江学者奖励计划”特聘教授，国家杰出青年基金获得者，肿瘤生物学国家重点实验室主要学术骨干。

专业特长：

长期从事胃肠疾病的基础和临床研究，在胃肠免疫学和肿瘤免疫学方面，尤其是胃癌化学预防、血管生成和炎症性肠病的研究中取得突出成绩。首先发现 COX2 促进胃癌进展的作用与其促血管生成有关，Ang-2 是介导 COX-2 促血管生成的重要下游靶分子；研制出能与胃癌血管内皮靶向性结合的多肽 GX1 ，其在胃癌血管特异性诊治中有良好的应用前景；率先研究并发现肠粘膜巨噬细胞参与炎症性肠病发病的机制。

 工作经历：

1997 年赴英国 Nottingham 大学攻读博士后，并先后在英国牛津大学和美国西北大学做访问学者。

科研与获奖：

先后获得国家杰出青年基金课题、国家“ 973 ”计划课题、国家“ 863 ”计划课题、国家自然科学基金国际合作课题、军队科技攻关等课题 20 余项。获国家发明专利3 项。2000年入选首批“高等学校骨干教师资助计划”，2002 年获得国家杰出青年基金，2005 年被批准为教育部“长江学者奖励计划”特聘教授， 2008 年获国家科技进步一等奖 1 项。

论文专著：

发表SCI 论文121篇，其中以第一作者及通讯作者发表 SCI 收录论文43 篇，总计影响因子为122.491，被61 种杂志引用 410 次，文章发表在Gut、Ann Intern Med 、 Carcinogenesis、Int J Cancer 等杂志。

学术任职：

中华医学会消化病学分会常委兼秘书长、亚太地区胃肠病学会常务理事兼奖励委员会主席等。 

主要论文：

1) Liu Z, Wang X, Lu Y, Han S, Zhang F, Zhai H, Lei T, Liang J, Wang J, Wu K, Fan D. Expression of 15-PGDH is down-regulated by COX-2 in gastric cancer. Carcinogenesis. 2008; 29(6):1219-1227. （ IF5.406 ）

2) Hui X, Han Y, Liu Z, Liu J, Hong L, Zhao L, He L, Liang S, Cao S, Chen B, Yan K, Jin B, Chai N, Wang J, Wu K, Fan D. Specific targeting of the vasculature of gastric cancer by a new tumor-homing peptide CGNSNPKSC. J Control Release. 2008; 131(2):86-93. （ IF4.756 ）

3) Leung WK, Wu KC, Wong CY, Cheng AS, Ching AK, Chan AW, Chong WW, Go MY, Yu J, To KF, Wang X, Chui YL, Fan DM, Sung JJ. Transgenic yclooxygenase-2 expression and high salt enhanced susceptibility tochemical-induced gastric cancer development in mice. Carcinogenesis. 2008 ； 29(8):1648-54. (IF5.406)

4) Leung WK, Wu MS, Kakugawa Y, Kim JJ, Yeoh KG, Goh KL, Wu KC, Wu DC, Sollano J, Kachintorn U, Gotoda T, Lin JT, You WC, Ng EK, Sung JJ; Asia Pacific Working Group on Gastric Cancer. Screening for gastric cancer in Asia: current evidence and practice. Lancet Oncol. 2008; 9(3):279-87. （ IF12.247 ）

5) Hong L, Wu K, Fan D. Drawing Conclusions about Short-Term Variability in Liver Function Test Results. Ann Intern Med. 2008;149(2):144-145. (IF15.516)

6) Hong L, Wu K, Fan D. Sildenafil as treatment for antidepressant-induced sexual dysfunction. JAMA. 2008;300(20):2365. (IF25.547)

7) Wu KC, Jackson LM, Galvin AM, Gray T, Hawkey CJ, Mahida YR. Phenotypic and functional characterisation of myofibroblasts, macrophages and lymphocytes migrating out of the human gastric laminal propria following the loss of epithelial cells. Gut. 1999; 94(3): 323. (IF6.17)

8) Jackson LM, Wu KC （ Co-firstauthor ） , Mahida YR, Jenkins D, Hawkey CJ. Cyclooxygenase (COX)-1 and -2 in normal, inflamed and ulcerated human gastric mucosa. Gut. 2000; 47(2): 762. (IF6.17)

9) Ning X, Sun S, Hong L, Liang J, Liu L, Han S, Liu Z, Shi Y, Li Y, Gong W, Zhang S, Chen Y, Guo X, Cheng Y, Wu K, Fan D. Calcyclin-binding protein inhibits proliferation, tumorigenicity, and invasion of gastric cancer. Mol Cancer Res. 2007; 5(12):1254-1262. (IF4.759)

10) Liu L, Sun L, Zhang H, Li Z, Ning X, Shi Y, Guo C, Han S, Wu K, Fan D. Hypoxia-mediated up-regulation of MGr1-Ag/37LRP in gastric cancers occurs via hypoxia-inducible-factor 1-dependent mechanism and contributes to drug resistance. Int J Cancer. 2009; 124(7):1707-1715. (IF4.555)

11) Liu L, Ning X, Sun L, Zhang H, Shi Y, Guo C, Han S, Liu J, Sun S, Han Z, Wu K, Fan D. Hypoxia-inducible factor-1alpha contributes to hypoxia-induced chemoresistance in gastric cancer. Cancer Sci. 2008; 99(1):121-128. (IF3.165)

12) Tang H, Wang J, Bai F, Hong L, Liang J, Gao J, Zhai H, Lan M, Zhang F, Wu K, Fan D. Inhibition of Osteopontin would suppress angiogenesis in gastric cancer. Biochem Cell Biol. 2007; 85(1):103-110. (IF3.483)

13) Wang J, Wu K, Bai F, Zhai H, Xie H, Du Y, Liang J, Han S, Chen Y, Lin T, Fan D. Celecoxib could reverse the hypoxia-induced Angiopoietin-2 upregulation in gastric cancer. Cancer Lett. 2006; 242(1):20-27. (IF3.049)

14) Chen Y, Wu K, Guo C, Liu C, Han S, Lin T, Ning X, Shi R, Shi Y, Fan D. A novel DNA vaccine containing four mimicry epitopes for gastric cancer. Cancer Biol Ther. 2005; 4(3):308-312. (IF3.279)

15) Shao XD, Wu KC, Hao ZM, Hong L, Zhang J, Fan DM. The potent inhibitory effects of Cisapride, a specific blocker for Human Ether-a-Go-Go-Related Gene (HERG) channel, on gastric cancer cells. Cancer Biol Ther. 2005; 4(3):295-301. (IF3.279)

16) Wu K, Nie Y, Guo C, Chen Y, Ding J, Fan D. Molecular basis of therapeutic approaches to gastric cancer. J Gastroenterol Hepatol. 2009;24(1):37-41. (IF1.718)

17) Chen B, Jin H, Wu K. Potential role of vascular targeted therapy to combat against tumor. Expert Opin Drug Deliv. 2009;6(7):719-726.

18) Cao S, Liu Y, Li X, Zhang Y, Wang J, Du W, Han Y, Jin H, Zhao L, Wu K*, Fan D. Expression, purification, and characterization of recombinant protein GX1-rmhTNFalpha. Mol Biotechnol. 2009;43(1):1-7. (IF1.859)

19) Chen B, Cao S, Zhang Y, Wang X, Liu J, Hui X, Wan Y, Du W, Wang L, Wu K, Fan D. A novel peptide (GX1) homing to gastric cancer vasculature inhibits angiogenesis and cooperates with TNF alpha in anti-tumor therapy. BMC Cell Biol. 2009;10:63. (IF2.652)

20) Jin B, Wang X, Jin Y, Xia W, Chen B, Liu L, Chen Z, Hong L, Du W, Yan K, Wang H, Yuan D, Hui X, He L, Zhang F, Zhao Y, Wu K, Fan D. Detection of serum gastric cancer-associated MG7-Ag from gastric cancer patients using a sensitive and convenient ELISA method. Cancer Invest. 2009;27(2):227-233. (IF1.849)

21) Liang J, Ge F, Guo C, Luo G, Wang X, Han G, Zhang D, Wang J, Li K, Pan Y, Yao L, Yin Z, Guo X, Wu K, Ding J, Fan D. Inhibition of PI3K/Akt partially leads to the inhibition of PrP(C)-induced drug resistance in gastric cancer cells. FEBS J. 2009;276(3):685-694.

22) Liang J, Wang J, Luo G, Pan Y, Han G, Wang X, Guo C, Zhang D, Yin F, Zhang X, Liu J, Wang J, Guo X, Wu K, Fan D. Function of PrP(C)(1-OPRD) in biological activities of gastric cancer cell lines. J Cell Mol Med. 2009. (IF3.606)

23) Chen Y, Wei X, Yan P, Han Y, Sun S, Wu K, Fan D. Human mitochondrial Mrs2 protein promotes multidrug resistance in gastric cancer cells by regulating p27, cyclin D1 expression and cytochrome C release. Cancer Biol Ther. 2009;8(7):607-614. (IF2.981)

24) Wu K, Jin JP. Calponin in non-muscle cells. Cell Biochem Biophys. 2008;52(3):139-148. (IF2.138)

出诊时间：周二上午（具体以当天公示为准）。