ALK EML4-ALK L1196M

在非小细胞肺癌患者中，表现出EML4-ALK融合，L1196M已被证明对环唑替尼具有耐药性。EML4-ALK C1156Y\U0026 L1196M患者也是如此。
In patients with non-small cell lung cancer exhibiting EML4-ALK fusion, L1196M has been shown to confer resistance to crizotinib. This was also true in a patient with both EML4-ALK C1156Y \u0026 L1196M.

别名

EML4-ALK LEU1196MET,RS1057519784
Allele Registry ID：CA16602593
ClinVar ID：376135

突变位点

Ref. Build: GRCh37 Ensembl Version: 75

Chr.	Start	Stop	Ref. s	Var. Bases
2	29443631	29443631	G	T
Transcript
ENST00000389048.3

基因序列

ENST00000389048.3:c.3586C>003eA
NC_000002.11:g.29443631G>003eT
NM_004304.4:c.3586C>003eA
NP_004295.2:p.Leu1196Met