TP53 DELETERIOUS MUTATION

有害突变是TP53的突变，其先前的特征表明对TP53蛋白功能有显著的有害影响。\n激活TP53突变可阻止MDM2-TP53相互作用抑制剂的靶向活性和功效。
Deleterious mutations are mutations of TP53 with prior characterization demonstrating significant deleterious effect on TP53 protein function.\nInactivating TP53 mutations prevent on target activity and efficacy of MDM2-TP53 interaction inhibitors.